Hydrochloric Acid → HCID 69315050, compound

Participants

Reaction Steps

To the solution of 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-formylphenyl)piperidin-3-one (300 mg, 0.62 mmol) obtained in Example 15 and sodium hydrogen phosphate (22 mg, NaH3PO4) in the mixed solvent of 1 ml of acetonitrile and 0.5 ml of water, was added 35%-hydrogen peroxide solution (0.1 ml) and 3 ml of sodium hypochlorite solution (NaClO4; 78 mg) at 10° C. The reaction mixture was stirred for about 1 hour at room temperature. Sodium sulfite (1.0 g) was added to the reaction mixture, which was then acidified with 10%-hydrochloride solution. The resulting solid was filtered and dried to give 150 mg of the titled compound.

Provenance & Evidence