m-Chloroperbenzoic acid → HCID 69312791, compound

Participants

Reaction Steps

To the solution of 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-formylphenyl)piperidin-3-ol (1.38 g, 2.8 mmol) obtained in Step 1 of Example 61 in 50 ml of chloroform, was added 486 mg of m-chloroperbenzoic acid (5.6 mmol). The reaction mixture was stirred for about 2 hours at room temperature. The resulting organic layer was washed with the solutions of sulfurous acid and sodium bicarbonate, dried on sodium sulfate. The resulting ester residue was dissolved in 100 ml of methanol and was added a drop of concentrated hydrochloride thereto. The reaction mixture was stirred for about 1 hour, was added sodium bicarbonate (0.5 g) thereto. The reaction mixture was concentrated. The resulting residue was purified with column chromatography to give 1.0 g of the titled compound.

Provenance & Evidence