反应详情

To the solution of methyl 1-[N-(furan-2-ylcarbonyl)amino]-1-cyclohexanecarboxylate (9.6 g) obtained in Step 1 in 100 ml of methanol, was added 2N-sodium hydroxide solution (50 ml). The reaction mixture was refluxed for 3 hours and concentrated. The resulting residue was diluted with 150 ml of water and washed with 100 ml of diethyl ether. 6N-hydrochloride was added dropwise to the resulting aqueous layer to adjust the pH of the solution to pH 3. The resulting white solid was filtered and dried to give the titled compound (6.1 g).

1. temperatureThe reaction mixture was refluxed for 3 hours
2. concentrationconcentrated
3. additionThe resulting residue was diluted with 150 ml of water
4. washwashed with 100 ml of diethyl ether
5. addition6N-hydrochloride was added dropwise to the resulting aqueous layer
6. filtrationThe resulting white solid was filtered
7. customdried