Triethylamine → 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-nitrophenyl)piperidin-3-ol

HRID 1392414Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1392414
Cl.[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH:9][C:10]1([C:16]([NH:18][CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH:20]2[OH:25])=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:8].F[C:27]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=1[N+:34]([O-:36])=[O:35].C(N(CC)CC)C>C(O)C>[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH:9][C:10]1([C:16]([NH:18][CH:19]2[CH2:24][CH2:23][N:22]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=3[N+:34]([O-:36])=[O:35])[CH2:21][CH:20]2[OH:25])=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:8]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 677672,5-DifluoronitrobenzeneHCID 693129954-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride

Produkt 1

HCID 693102044-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-nitrophenyl)piperidin-3-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To the solution of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride (6.0 g) obtained in Step 4 of Example 76 in 50 ml of ethanol, were added 2,5-difluoronitrobenzene (3.7 ml) and triethylamine (4.8 ml). The reaction mixture was refluxed overnight and concentrated. The resulting yellow solid was filtered and dried to give 7.2 g of the titled compound.

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed overnight
  2. concentrationconcentrated
  3. filtrationThe resulting yellow solid was filtered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-32fe0a73494a4cc08c23ded731469b18
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07342027B2

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