Sodium t-butoxide → HCID 69315548, compound

Participants

Reaction Steps

The solution of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-[4-fluoro-2-(3-chloro-2,2-dimethylpropionyl)aminophenyl]piperidin-3-ol (1.1 g) obtained in Step 1 in 40 ml of dichloromethane was cooled to 0° C. and was added sodium tert-butoxide (NaOtBu, 600 mg) thereto. The reaction mixture was stirred overnight at room temperature, diluted with dichloromethane, and washed with brine. The resulting organic layer was dried and concentrated on sodium sulfate. The resulting residue was purified with column chromatography to give 762 mg of the titled compound.

Provenance & Evidence