反应详情

The mixture of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-aminophenyl)piperidin-3-ol (3.0 g) obtained in Step 2 of Example 87 and 2,5-dimethoxytetrahydrofuran (0.96 ml) was refluxed in 80 ml of acetic acid for 1 hour. The reaction mixture was concentrated under reduced pressure. The resulting residue was diluted with 70 ml of dichloromethane and washed with a saturated sodium bicarbonate and brine. The resulting organic layer was dried and concentrated on sodium sulfate. The resulting residue was purified with column chromatography to give 1.8 g of the titled compound as white color.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionThe resulting residue was diluted with 70 ml of dichloromethane
3. washwashed with a saturated sodium bicarbonate and brine
4. customThe resulting organic layer was dried
5. concentrationconcentrated on sodium sulfate
6. customThe resulting residue was purified with column chromatography