Potassium Carbonate → HCID 69315069, compound

Participants

Reaction Steps

The mixture of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-formylhenyl)piperidin-3-ol (3.0 g, 6 mmol) obtained in Example 79, potassium carbonate (2 g, 20 mmol) and p-toluenesulfonylmethyl isocyanate (TosMIC; 1.8 g, 9 mmol) was refluxed in 500 ml of methanol for about 2 hours. The reaction mixture was concentrated, added water thereto, and extracted with dichloromethane. The resulting organic layer was dried and concentrated on sodium sulfate. The resulting residue was purified with column chromatography to give 3.2 g of the titled compound.

Provenance & Evidence