Triethylamine → HCID 11743912, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of 4-[N-[1-[N-(5-methyl-isoxazol-3-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-aminophenyl)piperidin-3-ol (1.1 g) obtained in Step 1 in 5 ml of dimethyl sulfoxide, was added 1.2 ml of triethylamine. The reaction mixture was cooled to 0° C. Pyridine-SO3 complex (0.9 g) was added to the reaction mixture, which was then stirred for about 4 hours at room temperature. The reaction mixture was diluted with 20 ml of ethyl acetate and washed with brine. The resulting organic layer was dried and concentrated on sodium sulfate. The resulting residue was filtered and dried to give 820 mg of the titled compound as white color.

Provenance & Evidence