HRID1392424

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67988

2-Bromo-1-chloro-4-(trifluoromethyl)benzene

C7H3BrClF3

结构：Cl.O=C(NC1(C(=O)NC2CCNCC2O)CCCCC1)c1cc2ccccc2s1

HCID69311888

未命名化合物

PRODUCTS

生成物

结构：O=C(NC1(C(=O)NC2CCN(c3cc(C(F)(F)F)ccc3Cl)CC2=O)CCCCC1)c1cc2ccccc2s1

HCID10348181

未命名化合物

PROCEDURE

实验过程

In accordance with the same procedure as in Example 85, except that 4-[N-[1-[N-(benzothiophen-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride was used instead of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride and 1-bromo-2-chloro-5-trifluoromethylbenzene was used instead of 1-bromo-4-fluoro-2-thiomethoxybenzene in Step 1 thereof, 222 mg of the titled compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a9f7274b2e4a473ab5b9cfe2fb7f85e5
来源数据集: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07342027B2
来源说明: uspto-grants-2008_03

反应 SMILES

Cl.[S:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[CH:4]=[C:3]1[C:11]([NH:13][C:14]1([C:20]([NH:22][CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH:24]2[OH:29])=[O:21])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:12].Br[C:31]1[CH:36]=[C:35]([C:37]([F:40])([F:39])[F:38])[CH:34]=[CH:33][C:32]=1[Cl:41]>>[S:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[CH:4]=[C:3]1[C:11]([NH:13][C:14]1([C:20]([NH:22][CH:23]2[CH2:28][CH2:27][N:26]([C:31]3[CH:36]=[C:35]([C:37]([F:39])([F:40])[F:38])[CH:34]=[CH:33][C:32]=3[Cl:41])[CH2:25][C:24]2=[O:29])=[O:21])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:12]