HRID1392427

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734909

2-Bromo-4-fluorobenzotrifluoride

C7H3BrF4

结构：Cc1c(C(=O)NC2(C(=O)NC3CCNCC3O)CCCCC2)oc2ccccc12.Cl

HCID69315007

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)NC2(C(=O)NC3CCN(c4cc(F)ccc4C(F)(F)F)CC3=O)CCCCC2)oc2ccccc12

HCID69310898

未命名化合物

PROCEDURE

实验过程

In accordance with the same procedure as in Example 85, except that 4-[N-[1-[N-(3-methyl-benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride was used instead of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride and 1-bromo-2-trifluoromethyl-5-fluorobenzene was used instead of 1-bromotoluene in Step 1 thereof, 128 mg of the titled compound was prepared.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-15305aea57e841b6b64d95bc29965b71
来源数据集: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07342027B2
来源说明: uspto-grants-2008_03

反应 SMILES

Cl.[CH3:2][C:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][C:4]=1[C:12]([NH:14][C:15]1([C:21]([NH:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH:25]2[OH:30])=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)=[O:13].Br[C:32]1[CH:37]=[C:36]([F:38])[CH:35]=[CH:34][C:33]=1[C:39]([F:42])([F:41])[F:40]>>[CH3:2][C:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][C:4]=1[C:12]([NH:14][C:15]1([C:21]([NH:23][CH:24]2[CH2:29][CH2:28][N:27]([C:34]3[CH:35]=[C:36]([F:38])[CH:37]=[CH:32][C:33]=3[C:39]([F:40])([F:41])[F:42])[CH2:26][C:25]2=[O:30])=[O:22])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1)=[O:13]