3-Bromo-4-methoxybenzonitrile → HCID 69310287, compound

HRID 1392428Notes

Reaction equation

HRID 1392428 reaction equation
Cl.[CH3:2][C:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][C:4]=1[C:12]([NH:14][C:15]1([C:21]([NH:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH:25]2[OH:30])=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)=[O:13].Br[C:32]1[CH:33]=[C:34]([CH:37]=[CH:38][C:39]=1[O:40][CH3:41])[C:35]#[N:36]>>[CH3:2][C:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][C:4]=1[C:12]([NH:14][C:15]1([C:21]([NH:23][CH:24]2[CH2:29][CH2:28][N:27]([C:32]3[CH:33]=[C:34]([C:35]#[N:36])[CH:37]=[CH:38][C:39]=3[O:40][CH3:41])[CH2:26][C:25]2=[O:30])=[O:22])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1)=[O:13]

Participants

3

Reactant 2

HCID 7360493-Bromo-4-methoxybenzonitrileHCID 69315007HCID 69315007, compound

Product 1

HCID 69310287HCID 69310287, compound

Procedure

In accordance with the same procedure as in Example 85, except that 4-[N-[1-[N-(3-methyl-benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride was used instead of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride and 3-bromo-4-methoxybenzonitrile was used instead of 1-bromotoluene in Step 1 thereof, 270 mg of the titled compound was prepared.

Sources & evidence

ORD record
ord-a9e87cb2e73a4611a86fcd3aec6c1256
Source dataset
uspto-grants-2008_03
Patent number
US07342027B2

Reaction notes

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