2-Bromo-5-fluorobenzotrifluoride → HCID 69315695, compound

HRID 1392431Notes

Reaction equation

Cl.[F:2][C:3]1[CH:27]=[CH:26][C:6]([C:7]([NH:9][C:10]2([C:16]([NH:18][CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH:20]3[OH:25])=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:8])=[CH:5][CH:4]=1.Br[C:29]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][C:30]=1[C:36]([F:39])([F:38])[F:37]>>[F:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:9][C:10]2([C:16]([NH:18][CH:19]3[CH2:24][CH2:23][N:22]([C:29]4[CH:34]=[CH:33][C:32]([F:35])=[CH:31][C:30]=4[C:36]([F:37])([F:39])[F:38])[CH2:21][C:20]3=[O:25])=[O:17])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]2)=[O:8])=[CH:26][CH:27]=1

Participants

Reactant 2

HCID 5209832-Bromo-5-fluorobenzotrifluoride

HCID 69312944HCID 69312944, compound

Product 1

HCID 69315695HCID 69315695, compound

Procedure

In accordance with the same procedure as in Example 85, except that 4-[N-[1-[N-(4-fluorobenzoyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride was used instead of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride and 1-bromo-4-fluoro-2-trifluoromethylbenzene was used instead of 1-bromo-4-fluoro-2-thiomethoxybenzene in Step 1 thereof, 137 mg of the titled compound was prepared.

Sources & evidence

ORD record: ord-5fa7e51119fa4ccb9d1d517b34bdf8c3
Source dataset: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07342027B2

Reaction notes

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