2,3,4-Trifluorobenzoyl chloride → HCID 69313101, compound

HRID 1392434Notes

Reaction equation

HRID 1392434 reaction equation
[F:1][C:2]1[CH:34]=[CH:33][C:5]([C:6]([NH:8][C:9]2([C:15]([NH:17][CH:18]3[CH2:23][CH2:22][N:21]([C:24]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=4[NH2:31])[CH2:20][CH:19]3[OH:32])=[O:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1.[F:35][C:36]1[C:44]([F:45])=[C:43]([F:46])[CH:42]=[CH:41][C:37]=1[C:38](Cl)=[O:39]>>[F:1][C:2]1[CH:34]=[CH:33][C:5]([C:6]([NH:8][C:9]2([C:15]([NH:17][CH:18]3[CH2:23][CH2:22][N:21]([C:24]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=4[NH:31][C:38](=[O:39])[C:37]4[CH:41]=[CH:42][C:43]([F:46])=[C:44]([F:45])[C:36]=4[F:35])[CH2:20][C:19]3=[O:32])=[O:16])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27340222,3,4-Trifluorobenzoyl chlorideHCID 69310272HCID 69310272, compound

Product 1

HCID 69313101HCID 69313101, compound

Procedure

In accordance with the same procedure as in Example 87, except that 4-[N-[1-[N-(4-fluorobenzoyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-aminophenyl)piperidin-3-ol was used instead of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-aminophenyl)piperidin-3-ol and 2,3,4-trifluorobenzoyl chloride was used instead of methoxyacetyl chloride in Step 3 thereof, 321 mg of the titled compound was prepared.

Sources & evidence

ORD record
ord-ef32655578f048e39547e44a25dbc41a
Source dataset
uspto-grants-2008_03
Patent number
US07342027B2

Reaction notes

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