3-Bromopentane → 1-(1-Ethylpropyl)-4-nitro-1H-imidazole

HRID 1392441Notes

Reaction equation

HRID 1392441 reaction equation
[N+:1]([C:4]1[N:5]=[CH:6][NH:7][CH:8]=1)([O-:3])=[O:2].Br[CH:10]([CH2:13][CH3:14])[CH2:11][CH3:12]>>[CH2:11]([CH:10]([N:7]1[CH:8]=[C:4]([N+:1]([O-:3])=[O:2])[N:5]=[CH:6]1)[CH2:13][CH3:14])[CH3:12]

Participants

3

Reactant 2

HCID 157383-BromopentaneHCID 178526856HCID 178526856, compound

Product 1

HCID 671643481-(1-Ethylpropyl)-4-nitro-1H-imidazole

Procedure

4-nitroimidazole was alkylated with 3-bromopentane to provide the title compound: 1H NMR (400 MHz, CDCl3) 0.84-0.90 (m, 6H), 1.71-1.82 (m, 2H), 1.86-1.96 (m, 2H), 3.79 (p, 1H, J=4.8 Hz), 7.41 (d, 1H, J=1.6 Hz), 7.73 (d, 1H, J=1.3 Hz); MS 184.2 m/z (M+1).

Sources & evidence

ORD record
ord-4c926beb89ef43d48d94109192d21b68
Source dataset
uspto-grants-2008_03
Patent number
US07342118B2

Reaction notes

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