(2S)-2-hydroxy-3,3-dimethylbutanoic acid → HCID 11646322, compound

HRID 1392461Notes

Reaction equation

HRID 1392461 reaction equation
[CH2:1]([CH:3]([N:6]1[CH:10]=[C:9]([NH:11][C:12](=[O:18])[CH:13]([NH2:17])[CH2:14][CH2:15][CH3:16])[N:8]=[CH:7]1)[CH2:4][CH3:5])[CH3:2].[OH:19][C@@H:20]([C:24]([CH3:27])([CH3:26])[CH3:25])[C:21](O)=[O:22]>>[CH2:1]([CH:3]([N:6]1[CH:10]=[C:9]([NH:11][C:12](=[O:18])[CH:13]([NH:17][C:21](=[O:22])[CH:20]([OH:19])[C:24]([CH3:27])([CH3:26])[CH3:25])[CH2:14][CH2:15][CH3:16])[N:8]=[CH:7]1)[CH2:4][CH3:5])[CH3:2]

Participants

3

Reactant 2

HCID 11097105(2S)-2-hydroxy-3,3-dimethylbutanoic acidHCID 671650412-Amino-pentanoic acid [1-(1-ethyl-propyl)-1H-imidazol-4-yl]-amide

Product 1

HCID 11646322HCID 11646322, compound

Procedure

2-Amino-pentanoic acid [1-(1-ethyl-propyl)-1H-imidazol-4-yl]-amide was coupled with (S)-2-hydroxy-3,3-dimethyl-butyric acid to provide the title compound: C13 NMR (100 MHz, CDCl3) 10.8, 13.9, 19.0, 26.3, 28.8, 35.3, 35.6, 52.7, 62.9, 79.8, 104.8, 132.7, 137.9, 169.2, 172.9; MS 367.1 m/z (M+1).

Sources & evidence

ORD record
ord-cfd4bf7c60c445c0bbb5643a9069f327
Source dataset
uspto-grants-2008_03
Patent number
US07342118B2

Reaction notes

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