HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-Hydroxy-3-methylbutanoic acid → 2-(2-Hydroxy-3-methyl-butyrylamino)-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-Hydroxy-3-methylbutanoic acid | HCID 853180 | — |
| Reactant | 2-Amino-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide | HCID 67164226 | — |
| Product | 2-(2-Hydroxy-3-methyl-butyrylamino)-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide | HCID 11654395 | — |
Reaction Steps
2-Amino-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide was coupled with (S)-2-hydroxy-3-methyl-butyric acid to afford the title compound: C13 NMR (100 MHz, CDCl3) 12.7, 15.2, 18.4, 18.9, 22.8, 25.3, 31.8, 33.9, 53.0, 56.8, 60.7, 63.3, 75.8, 107.5, 130.8, 131.1, 171.7, 175.7; MS m/z 408.5 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07342118B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-40416e68db6c4ec6a4f0eb3c79043f6a |
| Source note | uspto-grants-2008_03 |