2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid → HCID 11259464, compound

HRID 1392483Notes

Reaction equation

HRID 1392483 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C:4]([N:7]1[CH:11]=[C:10]([NH2:12])[N:9]=[C:8]1[CH3:13])([CH3:6])[CH3:5].[F:15][C:16]1[CH:17]=[C:18]([CH2:23][C:24]([NH:26][CH:27]([CH2:31][CH2:32][CH3:33])[C:28](O)=[O:29])=[O:25])[CH:19]=[C:20]([F:22])[CH:21]=1>>[CH3:1][O:2][C:3](=[O:14])[C:4]([N:7]1[CH:11]=[C:10]([NH:12][C:28](=[O:29])[CH:27]([NH:26][C:24](=[O:25])[CH2:23][C:18]2[CH:19]=[C:20]([F:22])[CH:21]=[C:16]([F:15])[CH:17]=2)[CH2:31][CH2:32][CH3:33])[N:9]=[C:8]1[CH3:13])([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 219429862-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acidHCID 67164839HCID 67164839, compound

Product 1

HCID 11259464HCID 11259464, compound

Procedure

2-(4-Amino-2-methyl-imidazol-1-yl)-2-methyl-propionic acid methyl ester was coupled with 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid to afford the title compound: C13 NMR (100 MHz, CDCl3) 13.8, 14.7, 18.9, 26.1, 26.7, 35.5, 42.9, 53.3, 61.1, 102.7, 105.3, 112.3, 112.5, 134.9, 138.9, 140.9, 169.5, 169.7, 173.4; MS m/z 451.2 (M+1).

Sources & evidence

ORD record
ord-ec52ff0236094587b9b80b1c20390ec7
Source dataset
uspto-grants-2008_03
Patent number
US07342118B2

Reaction notes

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