참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | ethyl (1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylate | HCID 66578655 | — |
| 용매 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 생성물 | 2-(4-Bromophenyl)cyclopropanecarboxylic acid | HCID 301541 | — |
반응 단계
To a solution of ester from step 1 in THF-MeOH (4:1, 0.5M) was added LiOH (3 eq, 2M) and the mixture was stirred at 50° C. for 1 h. The organic solvent evaporated, aqueous was acidified with HCl 1N and the acid extracted with EtOAc (3×). The organic was washed with brine, dried and solvent evaporated to afford 2-(4-bromophenyl)cyclopropanecarboxylic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07342024B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_03 |
|---|
| ORD ID | ord-8bac66ea71dd4c13863b8312e03e3ee3 |
|---|
| 출처 메모 | uspto-grants-2008_03 |
|---|
