HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 69160387, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone | HCID 2733812 | — |
| Reactant | HCID 69158073 | HCID 69158073 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 69160387 | HCID 69160387 | — |
Reaction Steps
A mixture of (cis)-1-{[2-(4-bromophenyl)cyclopropyl]carbonyl}-1H-imidazole (1 eq) from Step 1, (4R,5S)-(+)-4-methyl-5-phenyl-2-oxazolidinone (1.2 eq) or (−)-isomer and DBU (added at 0° C., 1.2 eq) in CH3CN (0.2M) was stirred at 0° C. for 4 h. The solvent evaporated and residue purified by flash chromatography (Hexane:EtOAc; 100:0 to 80:20) to afford each diastereoisomer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07342024B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-04e5bc3fb4f844108aa1a774ab191767 |
| Source note | uspto-grants-2008_03 |