Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triphenylarsine | HCID 11773 | — |
| Reactant | HCID 22391987 | HCID 22391987 | — |
| Reactant | HCID 69157506 | HCID 69157506 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 69158755 | HCID 69158755 | — |
Reaction Steps
A mixture of ester from step 2 (1.7 eq), dibromo from step 1 (1 eq), Pd2(dba)3 (0.05 eq) and triphenylarsine (0.25 eq) in DMF (0.05M) was heated at 80° C. for 2 h. The mixture was cooled to rt, diluted with EtOAc and water, the organic was washed with brine, dried and solvent evaporated. The residue was purified by flash chromatography (CH2Cl2:MeOH; 99:1 to 90:10) to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07342024B2 |
|---|
| Source dataset | uspto-grants-2008_03 |
|---|
| ORD ID | ord-d78fb4e02f3049d99d485f84b1b6469f |
|---|
| Source note | uspto-grants-2008_03 |
|---|
