HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → (+)-Methyl 2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | 2-(4-Bromo-2-fluorophenyl)cyclopropane-1-carboxylic acid | HCID 43810308 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (+)-Methyl 2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylate | HCID 69157593 | — |
Reaction Steps
To a solution of (+)-2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylic acid from step 7 (1 eq) in methylenechloride was added an ethereal solution of diazomethane until reaction is completed by TLC. The resulting mixture was concentrated. The crude ester was used as such in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07342024B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-5d3832655d794ff1aff3fa74ae65fa4c |
| Source note | uspto-grants-2008_03 |