Trimethylamine → Hexamethonium Bromide

HRID 1392806Notes

Reaction equation

HRID 1392806 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]Br.[CH3:9][N:10]([CH3:12])[CH3:11]>C(O)C>[Br-:1].[CH3:9][N+:10]([CH3:12])([CH3:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N+:10]([CH3:12])([CH3:11])[CH3:9].[Br-:1]

Participants

4

Reactant 2

HCID 1146TrimethylamineHCID 123681,6-Dibromohexane

Product 1

HCID 5938Hexamethonium Bromide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

37.38 g of 1,6-dibromohexane (purity=96%) and 82.35 g of trimethylamine solution (31-35% by weight in ethanol) are added to a 500 ml flask, and the necessary ethanol is immediately added for obtaining a suitable mixture of the different products that have been added while they are homogenised by magnetic stirring. The resulting mixture is kept at room temperature with constant stirring for 48 hours, and the solid that is formed is recovered by means of filtration and is thoroughly washed with ethyl acetate and diethyl ether. The white solid obtained is dried at room temperature for 12 hours.

Workup

  1. customfor obtaining
  2. additiona suitable mixture of the different products that
  3. additionhave been added while they
  4. customis kept at room temperature
  5. stirringwith constant stirring for 48 hours
  6. customthe solid that is formed
  7. filtrationis recovered by means of filtration
  8. washis thoroughly washed with ethyl acetate and diethyl ether
  9. customThe white solid obtained
  10. customis dried at room temperature for 12 hours

Sources & evidence

ORD record
ord-31c64a62321d45e0918da712d6a83d8b
Source dataset
uspto-grants-2008_03
Patent number
US07344696B2

Reaction notes

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