反应详情

4-(4-tert-butyldimethylsilyloxybutyl)phenylacetic acid (0.25 g, 0.775 mmol) dissolved in dry ether is added dropwise to a suspension of lithium aluminum hydride in ether (44.2 mg, 1.16 mmol). The reaction mixture is stirred for 5 hours after which water (45 μl), NaOH (15% solution, 45 μl) and water (135 μl) are successively added and the reaction mixture is stirred for a further 30 minutes. The resulting precipitate is filtered and washed with ether. The ether filtrate is then washed with water and dried. After concentrating the ether, the product obtained is purified by flash chromatography (silica gel; ethyl acetate/hexanes)

1. additionare successively added
2. filtrationThe resulting precipitate is filtered
3. washwashed with ether
4. washThe ether filtrate is then washed with water
5. customdried
6. concentrationAfter concentrating the ether
7. customthe product obtained
8. customis purified by flash chromatography (silica gel; ethyl acetate/hexanes)