tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate → 1-tert-butoxycarbonyl-2-methyl-4-{4-[1 (S)-(4-Bromophenyl)-ethyl]-3(R)-methylpiperazin-1-yl}-piperidine

HRID 1392901Notes

Reaction equation

HRID 1392901 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH:11]2[CH3:16])[CH3:9])=[CH:4][CH:3]=1.[C:17]([O:21][C:22]([N:24]1[CH2:29][CH2:28][C:27](=O)[CH2:26][CH:25]1[CH3:31])=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22]([N:24]1[CH2:29][CH2:28][CH:27]([N:13]2[CH2:14][CH2:15][N:10]([C@H:8]([C:5]3[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=3)[CH3:9])[C@H:11]([CH3:16])[CH2:12]2)[CH2:26][CH:25]1[CH3:31])=[O:23])([CH3:20])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 12992764tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylateHCID 649307071-[1-(4-Bromo-phenyl)-ethyl]-2-methyl-piperazine

Product 1

HCID 692103061-tert-butoxycarbonyl-2-methyl-4-{4-[1 (S)-(4-Bromophenyl)-ethyl]-3(R)-methylpiperazin-1-yl}-piperidine

Procedure

1-[1-(4-Bromo-phenyl)-ethyl]-2-methyl-piperazine (0.104 g) from preparation A step 4 was treated with 0.075 g 1-tert-butoxycarbonyl-2-methyl-4-oxo-piperidine from the previous step as described in preparation A step 5 to afford 1-tert-butoxycarbonyl-2-methyl-4-{4-[1 (S)-(4-Bromophenyl)-ethyl]-3(R)-methylpiperazin-1-yl}-piperidine.

Workup

  1. customas described in preparation A step 5

Sources & evidence

ORD record
ord-4053966bce854d579eec140f3b3d17ab
Source dataset
uspto-grants-2008_03
Patent number
US07345042B2

Reaction notes

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