Water → HCID 69201928, compound

Participants

Reaction Steps

To a solution of compound 11 (200 mg, 0.886 mmol) in dichloromethane (7.5 mL) were added 2-thiophene sulfonyl chloride (241 mg, 1.320 mmol) and triethylamine (220 mg, 2.169 mmol) under a N2 atmosphere. The reaction mixture was stirred at room temperature for 4 h. Water (10 mL) followed by dichloromethane (10 mL) were added to the reaction mixture and the organic layer was separated, dried on sodium sulphate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography using silica gel to give the compound 12i as a solid (300 mg, 91.4%). HPLC: 99.74% (Rt=7.22 min).

Provenance & Evidence