Calcium Sulfate Dihydrate → Naproxen

HRID 1392995Notes

Reaction equation

HRID 1392995 reaction equation
O.O.S([O-])([O-])(=O)=O.[Ca+2].CC(N)[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)CC1.CC(NC)[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)CC1.C[C@@]1(O)[C@H](NC)[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC1.OS(O)(=O)=O.[CH3:110][C@H:111]([C:124]([O-:126])=[O:125])[C:112]1[CH:117]=[CH:116][C:115]2[CH:118]=[C:119]([O:122][CH3:123])[CH:120]=[CH:121][C:114]=2[CH:113]=1.[Na+]>>[CH3:110][C@H:111]([C:124]([OH:126])=[O:125])[C:112]1[CH:117]=[CH:116][C:115]2[CH:118]=[C:119]([O:122][CH3:123])[CH:120]=[CH:121][C:114]=2[CH:113]=1

Participants

4

Reactant 3

HCID 24928Calcium Sulfate DihydrateHCID 9855350Gentamicin SulfateHCID 23681059Naproxen Sodium

Product 1

HCID 156391Naproxen

Procedure

A mixture of 1,000.0 mg calcium sulfate dihydrate (Fluka), 250.0 mg poly-L-lactide (M-10,000 g/mol), 49.7 mg gentamicin sulfate (AK 628) and 86.8 mg naproxen sodium salt (produced through the neutralization of naproxen (Fluka)) is ground up. 200 mg of this mixture, respectively, are pressed with a press at a pressure of 5 tons within a period of two minutes into disk-shaped molded bodies with a diameter of 13 mm.

Sources & evidence

ORD record
ord-578e1d3b185b4c7a8c07911e47d23720
Source dataset
uspto-grants-2008_03
Patent number
US07345024B2

Reaction notes

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