Phosgene → HCID 72355931, compound

Participants

Reaction Conditions

Reaction Steps

Compound 7B (125 mg, 0.36 mmol) was dissolved in dichloromethane (5 mL) and cooled to 0° C. Triethylamine (150 μL, 1.1 mmol) and phosgene (20% in toluene, 0.23 mL, 0.44 mmol) were added to it. The mixture was stirred at 0° C. for 3 hours. The reaction mixture was quenched with water, extracted with dichloromethane. The combined extracts were dried over Na2SO4, filtered and concentrated to give crude desired product (144.6 mg, 97.8%), which was used in next step without further purification.

Provenance & Evidence