1,3-Propanediol → HCID 67423120, compound

Participants

Reaction Steps

Compound 189A (30 mg, 0.074 mmol) and 1,3-propanediol (54μL, 0.061 mmol), were dissolved in pyridine (1 mL). The mixture was stirred at room temperature for 5 days. Stripped of pyridine, the crude reaction mixture was purified on silica gel column using 0.5% ammonium hydroxide and 5% methanol in dichloromethane to give the desired product (7.3 mg, 22.8% yield).

Provenance & Evidence