Thionyl Chloride → 4-Fluoro-2-nitrobenzoyl chloride

HRID 1393060Notes

Reaction equation

S(Cl)([Cl:3])=O.[F:5][C:6]1[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[C:8]([N+:15]([O-:17])=[O:16])[CH:7]=1>>[F:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([Cl:3])=[O:11])=[C:8]([N+:15]([O-:17])=[O:16])[CH:7]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 27374164-Fluoro-2-nitrobenzoic acid

Product 1

HCID 133524084-Fluoro-2-nitrobenzoyl chloride

Procedure

5 mL of thionyl chloride was added to 0.5 g of 4-fluoro-2-nitrobenzoic acid and stirred overnight. The thionyl chloride was removed to obtain the title compound.

Workup

customThe thionyl chloride was removed

Sources & evidence

ORD record: ord-5666f9b7f30b4b0e9fc6097d269591e7
Source dataset: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07345049B2

Reaction notes

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