Methanol → [5-(5-Amino-2-fluoro-phenyl)-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

HRID 139308Notes

Reaction equation

HRID 139308 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([c:14]2[c:15]([F:23])[cH:16][cH:17][c:18]([N+:20]([O-:21])=[O:22])[cH:19]2)([CH:24]([F:25])[F:26])[CH2:11][O:10][CH2:9]1)=[O:27].[CH3:30][OH:31].[H:28][H:29]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([c:14]2[c:15]([F:23])[cH:16][cH:17][c:18]([NH2:20])[cH:19]2)([CH:24]([F:25])[F:26])[CH2:11][O:10][CH2:9]1)=[O:27]

Participants

4

Reactant 3

HCID 887MethanolHCID 66666041[5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl esterHCID 178418361HCID 178418361, compound

Product 1

HCID 66665663[5-(5-Amino-2-fluoro-phenyl)-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-b246e74b27d84097af2b24c0e0d75375
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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