HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (4-{[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-phenoxy)-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (4-{Tert-butoxycarbonyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-phenoxy)-acetic acid ethyl ester | HCID 69218280 | — |
| Product | (4-{[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-phenoxy)-acetic acid ethyl ester | HCID 69220394 | — |
Reaction Steps
Analogously, to example 1.4, (4-{tert-butoxycarbonyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-phenoxy)-acetic acid ethyl ester was deprotected with TFA to give (4-{[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-phenoxy)-acetic acid ethyl ester, MS: 451 (MH+), MP: 153-155° C., dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07345067B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-398fd74abcc5405aa72834ef930fb952 |
| Source note | uspto-grants-2008_03 |