反应详情

9.10 g (41.4 mmol) of o-iodophenol was dissolved in 102 ml of acetone and treated subsequently at 0° C. with 14.8 g (1.1 eq.) of cesium carbonate and 4.57 ml (1.0 eq.) of ethyl bromoacetate. After vigorous stirring for 1 h at ambient temperature and filtration, the bulk of solvent was evaporated and the residue redissolved in EtOAc. Washing with water, drying over magnesium sulfate, and evaporation of the solvents finally produced 12.66 g of pure title compound as colorless oil, MS: 306.0 (M)+.

1. filtrationfiltration
2. customthe bulk of solvent was evaporated
3. dissolutionthe residue redissolved in EtOAc
4. washWashing with water
5. dry with materialdrying over magnesium sulfate, and evaporation of the solvents finally produced 12.66 g of pure title compound as colorless oil, MS