Trifluoroacetic acid → HCID 69218024, compound

Participants

Reaction Steps

0.360 g (0.62 mmol) of the above prepared (4-{tert-butoxycarbonyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-2,6-dimethyl-phenoxy)-acetic acid ethyl ester was dissolved in 6.25 ml of CH2Cl2 and treated dropwise with 1.59 ml of TFA (33 eq.). After additional 30 min at RT, the bulk of the solvents was removed i. V. and the residue distributed between cold NaHCO3-solution and EtOAc. Washing of the organic layer with cold water and brine, drying over magnesium sulfate, and evaporation of the solvents left 0.292 g of the title compound as off-white solid which was used as such for the next step, MS: 479.4 (MH)+.

Provenance & Evidence