Iodoethane → HCID 69220617, compound

Participants

Reaction Steps

0.102 g (0.21 mmol) of the above prepared (2,6-dimethyl-4-{[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-phenoxy)-acetic acid ethyl ester was dissolved in 1.5 ml of abs. DMSO and treated with 0.066 g (0.43 mmol) of ethyl iodide and 0.032 g (0.23 mmol) of K2CO3. After vigorously stirring for 18 h at ambient temperature, the reaction mixture was poured onto crashed ice/aqueous 10% KHSO4, extracted twice with EtOAc, the organic layer was washed with water and brine, dried over magnesium sulfate, and evaporated to dryness. Flash chromatography (SiO2, hexane/EtOAc=8/2), yielded finally 0.067 g of the title compound as yellow oil, MS: 507.6 (MH)+.

Provenance & Evidence