2-Methyl-4-nitrophenol → HCID 45097887, compound

Participants

Reaction Steps

A solution of methyl bromoacetate (15.76 ml, 171 mmol) and 2-methyl-4-nitrophenol (25.0 g, 163 mmol) in dry acetonitrile (300 ml) was treated with Cs2CO3 (61.3 g, 188 mmol) and stirred at RT for 4 h. The mixture was filtered, washed with acetonitrile and evaporated. The residue was suspended in CH2Cl2 (700 ml), filtered and evaporated to give 36.4 g of (2-methyl-4-nitro-phenoxy)-acetic acid methyl ester as yellow crystals, MS: 225 M+.

Provenance & Evidence