Acetic Acid → HCID 66858017, compound

Participants

Reaction Steps

A solution of (2-methyl-4-nitro-phenoxy)-acetic acid methyl ester (36.3 g, 161 mmol) in MeOH (400 ml) and AcOH (11.2 ml, 177 mmol) was hydrogenated in the presence of 10% Pd/C (3.63 g) for 7 h. After removal of the catalyst the reaction was evaporated, dissolved in toluene and evaporated (5×) to give 32.5 g of (4-amino-2-methyl-phenoxy)-acetic acid methyl ester as a brown crystallin residue, MS: 196 (MH+).

Provenance & Evidence