Sodium Iodide → HCID 69217922, compound

Participants

Reaction Steps

A suspension of potassium carbonate (45 mg, 0.33 mmol), sodium iodide (45 mg, 0.30 mmol) and of (2-iodo-4-methylamino-phenoxy)-acetic acid methyl ester (73 mg, 0.35 mmol) in DMSO (4 ml) was treated with 5-chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole (96 mg, 0.30 mmol, WO02/28433) in 3 portions over 1.5 h. The reaction mixture was stirred for total 2.5 h at RT, taken up in ether and washed with KHSO4-solution (10%). The organic phase was washed with NaCl (10%), dried (Na2SO4) and evaporated. Purification by flash chromatography (SiO2, n-heptane/AcOEt=4/1) gave 151 mg of pure (2-iodo-4-{methyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-phenoxy)-acetic acid methyl ester, MS: 577.2 (MH)+.

Provenance & Evidence