Lithium Hydroxide → HCID 11432974, compound

Participants

Reaction Steps

A solution of (2-iodo-4-{methyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-phenoxy)-acetic acid methyl ester (140 mg, 0.24 mmol) in THF (1.2 ml) and ethanol (1.2 ml) was treated at 0° C. with 1N LiOH (0.73 ml) and stirred for 3 h at RT. The reaction was extracted with aqueous 10% KHSO4/Et2O (3×). The organic phase was washed with aqueous 10% NaCl, dried over Na2SO4 and evaporated. The product was crystallized from CH2Cl2 to give 79 mg of pure (2-iodo-4-{methyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-phenoxy)-acetic acid, MS: 561.1 (M-H)−, MP: 172.5-173.0° C.

Provenance & Evidence