反应详情

10 g (0.02 moles) of (2-butyl-5-chloro-3-{2′-[2-(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-biphenyl-4-ylmethyl}-3H-imidazol-4-yl)-methanol are dissolved in 50 ml of dichloromethane and gaseous HCl is bubbled at a temperature of 0-10° C. After 2 h the reaction mixture is poured into a solution of 55 g of sodium acetate in water, the formed precipitate is filtered, thoroughly washed with water and dried under vacuum at 70° C., thereby obtaining 7.8 g of losartan.

1. customgaseous HCl is bubbled at a temperature of 0-10° C
2. additionAfter 2 h the reaction mixture is poured into a solution of 55 g of sodium acetate in water
3. filtrationthe formed precipitate is filtered
4. washthoroughly washed with water
5. customdried under vacuum at 70° C.