反应详情

9-benzyl-9-azabicyclo[3.3.1]nonan-3-one hydrochloride (38.8 g) was dissolved in 450 mL of glacial acetic acid. 13.5 Grams of 10% Pd/C (Degussa catalyst E101—containing 50% water) was added. After the appropriate evacuation & purge cycles, the mixture was agitated under 62 psi of H2 at rt overnight. TLC (3% MeOH in CH2Cl2 on silica gel) indicated that the reaction was complete. The reaction mixture was filtered through Celite and concentrated by rotary evaporation under vacuum. The product was redissolved in 0.12 N HCl (250 mL) and the solution was concentrated in vacuo. This was repeated once more with 0.12 N HCl (250 mL). The product was then dissolved in 1 N HCl and concentrated to dryness under vacuum. A sticky brown solid was obtained. The material was recrystallized once from isopropanol and once from EtOH to give 9-azabicyclo[3.3.1]nonan-3-one hydrochloride as a tan granular solid (18.8 g; 73.6% yield) after drying under high vacuum (0.1-1.0 mTorr) overnight.

1. customAfter the appropriate evacuation & purge cycles
2. filtrationThe reaction mixture was filtered through Celite
3. concentrationconcentrated by rotary evaporation under vacuum
4. dissolutionThe product was redissolved in 0.12 N HCl (250 mL)
5. concentrationthe solution was concentrated in vacuo
6. dissolutionThe product was then dissolved in 1 N HCl
7. concentrationconcentrated to dryness under vacuum
8. customA sticky brown solid was obtained
9. customThe material was recrystallized once from isopropanol and once from EtOH