反应详情

温度

100 °C

To a suspension of the enol-ketone (9-[(4-chlorophenyl)sulfonyl]-2-(hydroxymethylene)-9-azabicyclo[3.3.1]nonan-3-one, 34 mg, 0.10 mmol), sodium acetate (41 mg, 0.5 mmol) and glacial acetic acid (0.8 mL) in a vial was added the tert-butylhydrazine hydrochloride (31 mg, 0.25 mmol) with good stirring. The vial was capped and the reaction mixture was stirred evenly and heated to 100° C. Upon complete consumption of the enol-ketone (2-18 h, LC-MS), the reaction mixture was evaporated under a stream of nitrogen while being warmed in a 90° C. bath. The brown residue was dissolved with dichloromethane and water. The organic phase was washed with 5% NaHSO4 (3×), 5% NaHCO3 (2×), and brine (2×), dried (Na2SO4), applied to a silica gel column and eluted (0-10% EtOAc in dichloromethane) to yield the product upon evaporation. MS (ES) m/e 306.0 (M+H)+.

1. customThe vial was capped
2. customUpon complete consumption of the enol-ketone (2-18 h, LC-MS)
3. customthe reaction mixture was evaporated under a stream of nitrogen
4. temperaturewhile being warmed in a 90° C. bath
5. dissolutionThe brown residue was dissolved with dichloromethane and water
6. washThe organic phase was washed with 5% NaHSO4 (3×), 5% NaHCO3 (2×), and brine (2×)
7. dry with materialdried (Na2SO4)
8. washeluted (0-10% EtOAc in dichloromethane)
9. customto yield the product
10. customupon evaporation