9-(4-Chlorophenylsulfonyl)-2-(hydroxymethylene)-9-azabicyclo[3.3.1]nonan-3-one → 16-(4-Chloro-benzenesulfonyl)-6-acetamido-4,8,9,16-tetraaza-tetracyclo-[10,3,1,02,10,05,9]hexadeca-2(10),3,5,7-tetraene

HRID 1393253Notes

Reaction equation

HRID 1393253 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH:16]3[CH2:17][CH2:18][CH2:19][CH:12]2[C:13](=[CH:21]O)[C:14](=O)[CH2:15]3)(=[O:10])=[O:9])=[CH:4][CH:3]=1.S(O)(O)(=O)=O.[NH2:28][C:29]1[C:33](C(N)=O)=[CH:32][NH:31][N:30]=1.NC1[C:42]([C:43]([NH2:45])=[O:44])=CNN=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]2[CH:16]3[CH2:17][CH2:18][CH2:19][CH:12]2[C:13]2[CH:21]=[N:28][C:29]4[N:30]([C:14]=2[CH2:15]3)[N:31]=[CH:32][C:33]=4[NH:45][C:43](=[O:44])[CH3:42])(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 668419749-(4-Chlorophenylsulfonyl)-2-(hydroxymethylene)-9-azabicyclo[3.3.1]nonan-3-oneHCID 178513767HCID 178513767, compound

Product 1

HCID 6684234316-(4-Chloro-benzenesulfonyl)-6-acetamido-4,8,9,16-tetraaza-tetracyclo-[10,3,1,02,10,05,9]hexadeca-2(10),3,5,7-tetraene

Procedure

Prepared as described in Example 5 using 9-(4-chlorophenylsulfonyl)-2-(hydroxymethylene)-9-azabicyclo[3.3.1]nonan-3-one which was prepared as described in Example 34 and 3-amino-4-pyrazolecarboxamide hemisulfate salt.

Workup

  1. customPrepared
  2. customwas prepared

Sources & evidence

ORD record
ord-c90f565c573f45058221f12654dd071e
Source dataset
uspto-grants-2008_03
Patent number
US07345056B2

Reaction notes

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