Methyl Methacrylate → HCID 69287551, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.00 g of ((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-phosphinic acid and 18.3 ml of HN(TMS)2 was heated to 110° C. for 1 h. To the solution was added 2.5 ml of methyl methacrylate and heating was continued at 110° C. for 2 h. The solution was cooled to 70° slowly diluted with 10 ml of EtOH and evaporated. The residue was chromatographed on silica using a gradient of CH2Cl2/MeOH (9:1)→CH2Cl2/MeOH/AcOH (10:1:0.3) to give 4.10 g of the title compound. MS: 386.5 (M+H)+.

Provenance & Evidence