Lithium hydroxide, monohydrate → HCID 69288452, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2.11 g of 3-{[(R)-1-(3-dipropylcarbamoyl-benzoylamino)-2-phenyl-ethyl]-hydroxy-phosphinoyl}-2-methyl-propionic acid methyl ester in 8 ml of MeOH was treated with a solution of 865 mg of LiOH.H2O in 2 ml of H2O and the turbid solution was stirred at 20° C. for 1.5 h. The mixture was evaporated and the residue partitioned between aqueous HCl (pH=2) and AcOEt. The organic layer was washed with brine, dried and evaporated to give 1.54 g of the title compound. MS: 501.4 (M−H)—.

Provenance & Evidence