Sodium Hydroxide → HCID 178457265, compound

Participants

Reaction Steps

A solution of 14 mg of 3-{[1-(3-dipropylcarbamoyl-benzoylamino)-2-phenyl-ethyl]-hydroxy-phosphinoylmethyl}-N-phenyl-succinamic acid methyl ester (compound I-17) in 1 ml of MeOH and 3 mg of NaOH was warmed to 45° for 3 h. The solution was evaporated, the residue partitioned between 1N aqueous hydrochloric acid and CH2Cl2, the organic layer was washed with water, dried and evaporated to give 11 mg of 3-{[1-(3-di-propylcarbamoyl-benzoylamino)-2-phenyl-ethyl]-hydroxy-phosphinoylmethyl}-N-phenyl-succinamic acid (compound 1-53).

Provenance & Evidence