Sodium borohydride → HCID 24993629, compound

Participants

Reaction Steps

The title compound was prepared as a mixture of diastereomers from the intermediate of step A according to the procedure of Example 6, step C (NaBH4 in methanol). 1H-NMR (CDCl3): rotamers; δ: 7.71 (1 H, s), 7.23 (2 H, s), 7.00 (2 H, m), 6.93 (2 H, t, J=8.2 Hz), 4.88-4.65 (2 H, m), 4.46 (1 H, m), 4.07 (0.5 H, m), 3.83 (0.5 H, m), 3.55 (1 H, m), 3.35 (1 H, m), 3.28 (1 H, m), 2.97 (2 H, m), 2.92 (1 H, m), 2.58 (1 H, m), 2.43 (1 H, m), 2.25 (1 H, m), 2.13 (1 H, m), 2.05-1.85 (2 H, m), 1.70-1.55 (2 H, m), 1.30 (3 H, 2d, J=6.0 Hz). MS: (MH)+ 572.5 The diastereomers were separated by HPLC on CHIRACEL OD column eluting with hexanes/EtOH (85/15) to afford the individual diastereomers.

Provenance & Evidence