Sodium Hydroxide → HCID 11757843, compound

HRID 1393337Notes

Reaction equation

HRID 1393337 reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C@H:7]([CH3:12])[C:8]([O:10]C)=[O:9])=[CH:4][C:3]=1[CH2:15][N:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:25][C:26]([F:29])([F:28])[F:27])[CH:23]=2)[C:18]([C:30]2[C:34]3[CH:35]=[CH:36][C:37]([O:39][CH3:40])=[CH:38][C:33]=3[O:32][N:31]=2)=[C:17]1[CH3:41].[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C@H:7]([CH3:12])[C:8]([OH:10])=[O:9])=[CH:4][C:3]=1[CH2:15][N:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:25][C:26]([F:28])([F:27])[F:29])[CH:23]=2)[C:18]([C:30]2[C:34]3[CH:35]=[CH:36][C:37]([O:39][CH3:40])=[CH:38][C:33]=3[O:32][N:31]=2)=[C:17]1[CH3:41]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58818336HCID 58818336, compound

Product 1

HCID 11757843HCID 11757843, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 15 (312 mg, 0.46 mmol) in aqueous methanol was added a solution of 1.0M NaOH (1.5 eq). After 2 hours, reaction was complete by TLC. The solution was concentrated and purified by preparatory LC (C18, 100×20 mm I.D., 5 um). Product was isolated as a white amorphous solid.

Workup

  1. customreaction
  2. concentrationThe solution was concentrated
  3. custompurified by preparatory LC (C18, 100×20 mm I.D., 5 um)
  4. customProduct was isolated as a white amorphous solid

Sources & evidence

ORD record
ord-4e4a9bcf76fc4fd795d0462a7edfed3e
Source dataset
uspto-grants-2008_03
Patent number
US07345085B2

Reaction notes

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