Acetic Acid → HCID 69328059, compound

Participants

Reaction Steps

A mixture of 3,5-dichloro-N-trifluoroacetyl-O-[(6-methoxy)-2-naphthyl]-L-tyrosine methyl ester (160 mg, 0.31 mmol), 47% hydrobromic acid (3 ml) and acetic acid (2 ml) was heated under reflux for 5 hrs. The reaction mixture was diluted with water (10 ml), adjusted to pH 4-5 with 4N sodium hydroxide under ice cooling and then stirred at room temperature for 30 min. The precipitates were collected by filtration, washed with water and dried under reduced pressure to give 3,5-dichloro-O-[(6-hydoxy)-2-naphthyl]-L-tyrosine (92 mg, 76%) as a pale orange powder.

Provenance & Evidence