Hydrochloric Acid → HCID 69315009, compound

Participants

Reaction Steps

0.5 N Lithium hydroxide (1.6 ml, 0.8 mmol) was added to a solution of N-trifluoroacetyl-3-(2-naphthyloxy)-L-phenylalanine ethyl ester (94 mg, 0.219 mmol) in tetrahydrofuran (2 ml) at 5° C. and the mixture was reacted at 5° C. for 69 hrs. The reaction mixture was adjusted to pH 3-4 with 1N hydrochloric acid and the precipitates were collected by filtration. The resultant solid was washed with water and ethanol in turn and then dried to give 3-(2-naphthyloxy)-L-phenylalanine (57 mg, 78%) as a colorless solid.

Provenance & Evidence