HCID 69320527, compound → HCID 69321446, compound

Participants

Reaction Steps

Palladium hydroxide carbon (50% water content, 180 mg) was added to a solution of N-t-butoxycarbonyl-3-[(2-naphthoyl)methoxy]-L-phenylalanine methyl ester (400 mg, 0.863 mmol) in methanol (13 ml) and the mixture was stirred in hydrogen stream at room temperature for 20 hrs. The catalyst was filtered off and the solvent of the filtrate was distilled off under reduced pressure. The residue was purified by column chromatography on silica gel (n-hexane/ethyl acetate=7) to give N-t-butoxycarbonyl-3-[2-[2-(5,6,7,8-tetrahydro-naphthyl)]ethoxy]-L-phenylalanine methyl ester (132 mg, 34%) and methyl ester of N-t-butoxycarbonyl-3-[2-(2-naphthyl)ethoxy]-L-phenylalanine (134 mg, 34%) (in turn of elution).

Provenance & Evidence